Variation of fetal hemoglobin and F-cell number with the LCR-HS2 polymorphism in nonanemic individuals.
نویسندگان
چکیده
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinked to this region on erythrocytes termed F cells. The number of F cells in an individual chromosome 11.4."
منابع مشابه
Variation of Fetal Hemoglobin and F-Cell Number With the LCR-HS2 Polymorphism in Nonanemic Individuals
To the Editor: remains const t and seems to be under genetic control.' Available data suggest that at least two types of genetic determinants might In normal adults. synthesis of fetal hemoglobin (HbF) persists at be involved in the level of HbF expression: one linked to the pa very low level ( < I % ) and is restricted to a subpopulation of globin gene cluste?.' and the other(s) unlinke...
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The fetal hemoglobin (HbF) levels and betaS-globin gene haplotypes of 125 sickle cell anemia patients from Brazil were investigated. We sequenced the Ggamma- and Agamma-globin gene promoters and the DNase I-2 hypersensitive sites in the locus control regions (HS2-LCR) of patients with HbF level disparities as compared to their betaS haplotypes. Sixty-four (51.2%) patients had CAR/Ben genotype; ...
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We have examined the pattern of human globin gene switching in transgenic mice containing three different gamma and beta gene constructs (HS2G gamma A gamma delta beta, HS2A gamma beta neo, and HS2A gamma en beta) and compared the results with previously described transgenics (HS2A gamma beta, HS2G gamma A gamma-117 delta beta, and LCR epsilon G gamma A gamma delta beta). Developmental regulati...
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The clinical and hematological course of β thalassemia intermedia is influenced by a number of genetic factors which play a role in increasing fetal haemoglobin levels. Several polymorphisms located in the promoters of β and γ globin gene are involved in influencing the disease severity. Our objective was to study the effect of cis-DNA haplotypes, motifs, or polymorphisms (Pre G γ globin gene h...
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عنوان ژورنال:
- Blood
دوره 87 6 شماره
صفحات -
تاریخ انتشار 1996